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Abstract

Summary and overview of the biological impact, influence and effects of new carbon fullerene on cell health; with the focus on an antioxidant function resulting in anti-aging effects combined with life-prolonging. In particular, focused on functions and results of various healing properties and on tested toxic behaviours that have been reported for fullerenes and its derivatives in newest publications. The overview starts with the story of fullerene-discovery and the most important properties, functions and effects of carbon fullerenes. This especially with regard of human lifespan extensions due to some antioxidative effects of C60 fullerenes. In comparison with available experimental data and theoretical modelling, a critical consideration and assessment will be developed. Particular attention is paid to a new hypothesis that fullerenes as proton donors (H +) in mitochondria in various simulations of the transport of C60 through lipid bilayer membranes, with their ability to absorb reactive oxygen species. And their degradation activity can act as mild decouplers in mitochondrial respiration. One of the problems that has hitherto complicated the use of fullerene in medicinal chemistry has been its insolubility in water and in water-based liquids. The report created here shows which C60 derivatives nevertheless allow water solubility and how other C60 carriers are used for health-promoting applications. Such carriers are generally fatty glycerol esters or free fatty acids which enable the solubility of C60 fullerene in vegetable oils, namely: olive, sunflower or peanut oils. These results pave the way for use of certain carbon fullerene derivatives in water as well as apply of classic C60 fullerene in vegetable oils as vehicles in the delivery and intake of fullerene for both oral use and vaccine development.

La molécula C60 corresponde a un átomo de carbono con una forma semejante a un balón de fútbol con sesenta lados, de los cuales cada pico corresponde a un átomo. Resulta más duro que el diamante bajo presión, sin embargo, es suave y delicado cuándo no está sometido a presión y es también muy estable.